产品
编 号：F429241
分子式：C7H15NO4
分子量：177.2
分子式：C7H15NO4
分子量：177.2
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 69567-10-8
产品详情
生物活性：
N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
体内研究：
N-Methylmoranoline decreases the alpha-1,6-glucosidase activity to approximately 20%, reduces the glycogen breakdown, and attenuates the lactate accumulation at both 10 and 30 minutes of ischemia. MOR-14 is protective against postischemic left ventricular dysfunction through the inhibition of glycogenolysis in the isolated rat heart.
体外研究：
N-Methylmoranoline dose-dependently decreases the α-1,6-glucosidase activity in rabbit heart extract. The myocardial uptake of a considerable amount of N-Methylmoranoline is sufficient to fully inhibit alpha-1,6-glucosidase. Preischemic treatment with 25, 50, and 100 mg/kg of N-Methylmoranoline dose-dependently reduces the infarct size without altering the blood pressure or heart rate. MOR-14 significantly increases levels of PKC-ε in the particulate fraction at 20 and 30?min of ischaemia and in the cytosolic fraction at 30?min of ischaemia.
N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
体内研究：
N-Methylmoranoline decreases the alpha-1,6-glucosidase activity to approximately 20%, reduces the glycogen breakdown, and attenuates the lactate accumulation at both 10 and 30 minutes of ischemia. MOR-14 is protective against postischemic left ventricular dysfunction through the inhibition of glycogenolysis in the isolated rat heart.
体外研究：
N-Methylmoranoline dose-dependently decreases the α-1,6-glucosidase activity in rabbit heart extract. The myocardial uptake of a considerable amount of N-Methylmoranoline is sufficient to fully inhibit alpha-1,6-glucosidase. Preischemic treatment with 25, 50, and 100 mg/kg of N-Methylmoranoline dose-dependently reduces the infarct size without altering the blood pressure or heart rate. MOR-14 significantly increases levels of PKC-ε in the particulate fraction at 20 and 30?min of ischaemia and in the cytosolic fraction at 30?min of ischaemia.
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