产品
编 号：F428562
分子式：C16H23N3OS
分子量：305.44
分子式：C16H23N3OS
分子量：305.44
产品类型
规格
价格
是否有货
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 69327-76-0
产品详情
生物活性：
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase.
体内研究：
扑虱灵 (46.3, 139, 417 mg/kg; p.o.; single) 在肝脏 (35.84%)、大脑 (23.58%)、胃 (21.94%) 和肾脏 (18.64%) 中积累。扑虱灵 (46.3, 139, 417 mg/kg; p.o.; single) 使小鼠所有器官（尤其是肝脏和大脑）的 MDA 水平升高。Animal Model:Male C57BL/6 mice (6 to 8-week-old).
Dosage:46.3, 139, 417 mg/kg
Administration:Oral administration; single
Result:Tended to elevate the MDA level in all organs, and the most significant concentration-dependent increases were observed in the liver and brain.Exhibited the highest concentrations in the liver (35.84%) followed by the brain (23.58%), stomach (21.94%) and kidney (18.64%), while the levels in the mouse spleen and heart were below the limit of detection.
体外研究：
扑虱灵 (100, 300, 1000 μM) 显著抑制 HepG2 细胞活力。扑虱灵 (3, 10, 30 μM; 24 h) 促进 HepG2 细胞的能量代谢从有氧三羧酸 (TCA) 循环和氧化磷酸化向无氧糖酵解的转化。扑虱灵 (3, 10, 30 μM; 24 h) 在 HepG2 细胞中抑制 Complex IV 的活性。
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase.
体内研究：
扑虱灵 (46.3, 139, 417 mg/kg; p.o.; single) 在肝脏 (35.84%)、大脑 (23.58%)、胃 (21.94%) 和肾脏 (18.64%) 中积累。扑虱灵 (46.3, 139, 417 mg/kg; p.o.; single) 使小鼠所有器官（尤其是肝脏和大脑）的 MDA 水平升高。Animal Model:Male C57BL/6 mice (6 to 8-week-old).
Dosage:46.3, 139, 417 mg/kg
Administration:Oral administration; single
Result:Tended to elevate the MDA level in all organs, and the most significant concentration-dependent increases were observed in the liver and brain.Exhibited the highest concentrations in the liver (35.84%) followed by the brain (23.58%), stomach (21.94%) and kidney (18.64%), while the levels in the mouse spleen and heart were below the limit of detection.
体外研究：
扑虱灵 (100, 300, 1000 μM) 显著抑制 HepG2 细胞活力。扑虱灵 (3, 10, 30 μM; 24 h) 促进 HepG2 细胞的能量代谢从有氧三羧酸 (TCA) 循环和氧化磷酸化向无氧糖酵解的转化。扑虱灵 (3, 10, 30 μM; 24 h) 在 HepG2 细胞中抑制 Complex IV 的活性。
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