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编 号：F428319
分子式：C22H26F3N3OS
分子量：437.52
分子式：C22H26F3N3OS
分子量：437.52
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CAS No: 69-23-8
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生物活性：
Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
体内研究：
Fluphenazine (1 mg/kg；IG，从妊娠第 6 天到第 15 天进行) 会导致怀孕小鼠畸形。Fluphenazine (0.125-1 mg/kg；IP，单剂量) 拮抗哌醋甲酯引起的刻板啃咬， 显着抑制攀爬行为。Animal Model:Mice (injected with 60 mg/kg Methylphenidate)
Dosage:0.125, 0.25, 0.5, and 1 mg/kg
Administration:IP, single dosage
Result:Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
Animal Model:Mature female Swiss-Webster mice
Dosage:1 mg/kg
Administration:IG, treated from day 6 to day 15 of gestation
Result:Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
体内研究：
Fluphenazine (1 mg/kg；IG，从妊娠第 6 天到第 15 天进行) 会导致怀孕小鼠畸形。Fluphenazine (0.125-1 mg/kg；IP，单剂量) 拮抗哌醋甲酯引起的刻板啃咬， 显着抑制攀爬行为。Animal Model:Mice (injected with 60 mg/kg Methylphenidate)
Dosage:0.125, 0.25, 0.5, and 1 mg/kg
Administration:IP, single dosage
Result:Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
Animal Model:Mature female Swiss-Webster mice
Dosage:1 mg/kg
Administration:IG, treated from day 6 to day 15 of gestation
Result:Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
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