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编 号:F428270
分子式:C20H23N3O
分子量:321.42
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.

体外研究:
CM10 (12.5、25、50、100 μM;1 小时) 抑制活细胞中的 ALDEFLUOR 活性并优先清除 CD133+ 卵巢癌干细胞样细胞 (CSC)。 CM10 诱导细胞/核肿胀坏死表型。
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