产品
编 号：F427846
分子式：C17H20Cl2N2S
分子量：355.33
分子式：C17H20Cl2N2S
分子量：355.33
产品类型
规格
价格
是否有货
100mg
194
In-stock
500mg
320
In-stock
1g
468
In-stock
5g
760
In-stock
结构图
CAS No: 69-09-0
产品详情
生物活性：
Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.
体内研究：
Chlorpromazine hydrochloride (20 mg/kg；腹腔注射；每日一次，持续 7 天) 抑制裸鼠体内的异种移植肿瘤生长。Animal Model:5- to 6-week-old athymic nude mice bearing intracranial U-87MG xenograft tumors.
Dosage:20 mg/kg
Administration:Injected intraperitoneally; single daily for 7 days
Result:Inhibited tumor growth on day 17.
体外研究：
Chlorpromazine hydrochloride (0，10，20，40 μM；0，24，48 h) 以剂量和时间依赖的方式抑制 U-87MG 神经胶质瘤细胞的生长。Chlorpromazine hydrochloride (20 μM；0、12、24、48 小时) 降低 U-87MG 神经胶质瘤细胞中细胞周期蛋白 A 和细胞周期蛋白 B1 的水平，12 小时后。 Chlorpromazine hydrochloride (20 μM) 抑制细胞周期进程。 Chlorpromazine hydrochloride (10 μM；1 h) 显著抑制 sEV 内化并显著减少经 sEV 处理的骨骼中的 MDSCs骨髓细胞 (MDSCs可显著抑制免疫细胞反应，引起癌细胞免疫抑制)。Chlorpromazine hydrochloride (3，10，20，40，60 μM) 阻断hNa v1.7 电流呈浓度依赖性。Chlorpromazine hydrochloride 阻断 HERG 钾通道，IC50 值为21.6 μM，希尔系数为 1.11。
Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.
体内研究：
Chlorpromazine hydrochloride (20 mg/kg；腹腔注射；每日一次，持续 7 天) 抑制裸鼠体内的异种移植肿瘤生长。Animal Model:5- to 6-week-old athymic nude mice bearing intracranial U-87MG xenograft tumors.
Dosage:20 mg/kg
Administration:Injected intraperitoneally; single daily for 7 days
Result:Inhibited tumor growth on day 17.
体外研究：
Chlorpromazine hydrochloride (0，10，20，40 μM；0，24，48 h) 以剂量和时间依赖的方式抑制 U-87MG 神经胶质瘤细胞的生长。Chlorpromazine hydrochloride (20 μM；0、12、24、48 小时) 降低 U-87MG 神经胶质瘤细胞中细胞周期蛋白 A 和细胞周期蛋白 B1 的水平，12 小时后。 Chlorpromazine hydrochloride (20 μM) 抑制细胞周期进程。 Chlorpromazine hydrochloride (10 μM；1 h) 显著抑制 sEV 内化并显著减少经 sEV 处理的骨骼中的 MDSCs骨髓细胞 (MDSCs可显著抑制免疫细胞反应，引起癌细胞免疫抑制)。Chlorpromazine hydrochloride (3，10，20，40，60 μM) 阻断hNa v1.7 电流呈浓度依赖性。Chlorpromazine hydrochloride 阻断 HERG 钾通道，IC50 值为21.6 μM，希尔系数为 1.11。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备