产品
编 号：F427776
分子式：C21H21ClO12
分子量：500.84
分子式：C21H21ClO12
分子量：500.84
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 6906-38-3
产品详情
生物活性：
Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL). Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 μM. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction.
体内研究：
Delphinidin 3-glucoside chloride (40 mg/kg/day，灌胃，25 天) 抑制 MDA-MB-231-Luc-GFP 异种移植的无胸腺 BALB/c 小鼠的肿瘤生长。Delphinidin 3-glucoside chloride (50 μM，静脉注射) 抑制 FeCl3 诱导的 C57BL/6 小鼠肠系膜小动脉损伤时的血栓生长。Animal Model:MDA-MB-231-Luc-GFP xenografted athymic BALB/c mice
Dosage:40 mg/kg/day
Administration:i.g., for 25 days
Result:Inhibited tumor growth.
体外研究：
Delphinidin 3-glucoside chloride (30-100 μM) 通过对氧化还原敏感的 caspase 3 激活诱导 B CLL 细胞凋亡 (apoptosis)。Delphinidin 3-glucoside chloride (0-40 μM) 通过 pAKT/IRF1 信号通路下调 HOTAIR 表达，对乳腺癌细胞和致癌物诱导的乳腺癌发生具有抑制活性。Delphinidin 3-glucoside chloride (1-100 μM) 通过钠依赖型葡萄糖转运蛋白 (SGLT1) 抑制 oxLDL 诱导的 HUVEC 内皮功能障碍。Delphinidin 3-glucoside chloride (0-50 μM) 通过抑制 AMPK 磷酸化来抑制 ADP、胶原蛋白或 TRAP 刺激引起的血小板聚集。
Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL). Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 μM. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction.
体内研究：
Delphinidin 3-glucoside chloride (40 mg/kg/day，灌胃，25 天) 抑制 MDA-MB-231-Luc-GFP 异种移植的无胸腺 BALB/c 小鼠的肿瘤生长。Delphinidin 3-glucoside chloride (50 μM，静脉注射) 抑制 FeCl3 诱导的 C57BL/6 小鼠肠系膜小动脉损伤时的血栓生长。Animal Model:MDA-MB-231-Luc-GFP xenografted athymic BALB/c mice
Dosage:40 mg/kg/day
Administration:i.g., for 25 days
Result:Inhibited tumor growth.
体外研究：
Delphinidin 3-glucoside chloride (30-100 μM) 通过对氧化还原敏感的 caspase 3 激活诱导 B CLL 细胞凋亡 (apoptosis)。Delphinidin 3-glucoside chloride (0-40 μM) 通过 pAKT/IRF1 信号通路下调 HOTAIR 表达，对乳腺癌细胞和致癌物诱导的乳腺癌发生具有抑制活性。Delphinidin 3-glucoside chloride (1-100 μM) 通过钠依赖型葡萄糖转运蛋白 (SGLT1) 抑制 oxLDL 诱导的 HUVEC 内皮功能障碍。Delphinidin 3-glucoside chloride (0-50 μM) 通过抑制 AMPK 磷酸化来抑制 ADP、胶原蛋白或 TRAP 刺激引起的血小板聚集。
产品资料
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