产品
编 号：F427261
分子式：C13H16N3NaO4S
分子量：333.34
分子式：C13H16N3NaO4S
分子量：333.34
产品类型
规格
价格
是否有货
500mg
480
In-stock
结构图
CAS No: 68-89-3
产品详情
生物活性：
Metamizole sodium (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor. Metamizole sodium can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium has anti-inflammatory and antioxidant activities. Metamizole sodium is an antipyretic, analgesic and spasmolytic agent. .Metamizole sodium can be used in research to relieve a variety of pain.
体内研究：
Metamizole sodium(500 mg/kg, 腹腔注射, 一天两次连续7 天) 可减少大鼠神经性疼痛症状的发展。Metamizole sodium(250 或 500 mg/kg, 口服 ) 可有效缓解大鼠刀切和卡拉胶诱导的疼痛和氧化应激反应。Animal Model:Male Wistar rats (270-300 g), with peripheral neuropathic pain
Dosage:500 mg/kg
Administration:Intraperitoneal injection, twice a day, for 7 days
Result:Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.
Animal Model:Pain model in rats
Dosage:250 or 500 mg/kg
Administration:p.o.
Result:Decreased the COX-2 gene expression at 500 mg/kg and increased the MPO gene expression.Reduced MDA levels in the carrageenan paw test and increased tGSH levels.
体外研究：
Metamizole sodium (1 和 10 μM, 24 h) 可抑制成骨细胞分化过程，从而降低其产生新的骨矿化细胞外基质的能力。Metamizole sodium (1-500 μM, 48 h) 在胰腺癌细胞系 PaTu 8988 t 和 Panc-1 中可抑制细胞增殖，促进细胞凋亡。
Metamizole sodium (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor. Metamizole sodium can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium has anti-inflammatory and antioxidant activities. Metamizole sodium is an antipyretic, analgesic and spasmolytic agent. .Metamizole sodium can be used in research to relieve a variety of pain.
体内研究：
Metamizole sodium(500 mg/kg, 腹腔注射, 一天两次连续7 天) 可减少大鼠神经性疼痛症状的发展。Metamizole sodium(250 或 500 mg/kg, 口服 ) 可有效缓解大鼠刀切和卡拉胶诱导的疼痛和氧化应激反应。Animal Model:Male Wistar rats (270-300 g), with peripheral neuropathic pain
Dosage:500 mg/kg
Administration:Intraperitoneal injection, twice a day, for 7 days
Result:Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.
Animal Model:Pain model in rats
Dosage:250 or 500 mg/kg
Administration:p.o.
Result:Decreased the COX-2 gene expression at 500 mg/kg and increased the MPO gene expression.Reduced MDA levels in the carrageenan paw test and increased tGSH levels.
体外研究：
Metamizole sodium (1 和 10 μM, 24 h) 可抑制成骨细胞分化过程，从而降低其产生新的骨矿化细胞外基质的能力。Metamizole sodium (1-500 μM, 48 h) 在胰腺癌细胞系 PaTu 8988 t 和 Panc-1 中可抑制细胞增殖，促进细胞凋亡。
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