产品
编 号：F427067
分子式：C15H24N2O
分子量：248.36
分子式：C15H24N2O
分子量：248.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
224
In-stock
10mg
320
In-stock
20mg
480
In-stock
50mg
920
In-stock
结构图
CAS No: 6882-68-4
产品详情
生物活性：
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity.
体内研究：
Sophoridine (intraperitoneal injection; 20 or 40 mg/kg; 21 days) can inhibit the growth of xenograft pancreatic tumors.Animal Model:BALB/c homozygous (nu/nu) nude mice
Dosage:20 or 40 mg/kg
Administration:Intraperitoneal injection; 20 or 40 mg/kg; 21 days
Result:Decreased xenograft pancreatic tumors mass.
体外研究：
Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM.Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively.Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio.
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity.
体内研究：
Sophoridine (intraperitoneal injection; 20 or 40 mg/kg; 21 days) can inhibit the growth of xenograft pancreatic tumors.Animal Model:BALB/c homozygous (nu/nu) nude mice
Dosage:20 or 40 mg/kg
Administration:Intraperitoneal injection; 20 or 40 mg/kg; 21 days
Result:Decreased xenograft pancreatic tumors mass.
体外研究：
Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM.Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively.Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio.
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