产品
编 号：F426936
分子式：C12H13N3O2
分子量：231.25
分子式：C12H13N3O2
分子量：231.25
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CAS No: 68-76-8
产品详情
生物活性：
Trenimon is a compound with anti-cancer effects. Trenimon shows mutagenic actions in many species by inducing point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction. Trenimon can be used for the research of cancer.
体内研究：
Trenimon (0.25 mg/kg; i.p. once) rapidly depresseas of the cellular elements of the peripheral blood (granulocytes, lymphocytes, reticulocytes, platelets and erythrocytes), and reduces the cell number of bone marrow.Trenimon (0.03 mg/kg; i.v. once per week for 52 weeks) shows an cancerogenic effect in vivo.Animal Model:BR 46 male rats
Dosage:0.03 mg/kg
Administration:Intravenous injection; 0.03 mg/kg once per week for 52 weeks
Result:Showed an cancerogenic effect and 24% animals developed malign tumors, and showed a induction time of the tumors is 16 months.
体外研究：
Trenimon (0.17 mM) penetrates readily into mouse lymphoma cells in vitro.Trenimon (0.17 nM; 5 min-16 h) time-denpendently reduces the priming activity of DNA.Trenimon (1 nM-10 μM; 10-20 min) leds HeLa cells death after 2 weeks with a dose of 10 μM and dose-dependently suppresses mitosis in cells.
Trenimon is a compound with anti-cancer effects. Trenimon shows mutagenic actions in many species by inducing point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction. Trenimon can be used for the research of cancer.
体内研究：
Trenimon (0.25 mg/kg; i.p. once) rapidly depresseas of the cellular elements of the peripheral blood (granulocytes, lymphocytes, reticulocytes, platelets and erythrocytes), and reduces the cell number of bone marrow.Trenimon (0.03 mg/kg; i.v. once per week for 52 weeks) shows an cancerogenic effect in vivo.Animal Model:BR 46 male rats
Dosage:0.03 mg/kg
Administration:Intravenous injection; 0.03 mg/kg once per week for 52 weeks
Result:Showed an cancerogenic effect and 24% animals developed malign tumors, and showed a induction time of the tumors is 16 months.
体外研究：
Trenimon (0.17 mM) penetrates readily into mouse lymphoma cells in vitro.Trenimon (0.17 nM; 5 min-16 h) time-denpendently reduces the priming activity of DNA.Trenimon (1 nM-10 μM; 10-20 min) leds HeLa cells death after 2 weeks with a dose of 10 μM and dose-dependently suppresses mitosis in cells.
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