产品
编 号：F426113
分子式：C18H27NO2
分子量：289.41
分子式：C18H27NO2
分子量：289.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
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50mg
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100mg
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询价
结构图
CAS No: 68489-09-8
产品详情
生物活性：
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.
体内研究：
Acoltremon (intraperitoneal injection; 10 mg/kg; once) shows analgesic effect by selective TRPM8 activation in mice.Animal Model:Trpm8–/– mice and mice injected with Capsaicin
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg; once
Result:Produced an obvious analgesic effect, and this effect abolished in Trpm8–/– mice.Showed no change falling latencies in mice in the rotarod test.Reduced Capsaicin-induced nocifensive behavior.
体外研究：
Acoltremon (10 μM) shows TRPM8 agonism in tests on heterologously expressed TRP ion channels.Acoltremon (1 or 10 μM; 0-250 s) shows highly potent and specific TRPM8 channel agonist in DRG neurons.
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.
体内研究：
Acoltremon (intraperitoneal injection; 10 mg/kg; once) shows analgesic effect by selective TRPM8 activation in mice.Animal Model:Trpm8–/– mice and mice injected with Capsaicin
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg; once
Result:Produced an obvious analgesic effect, and this effect abolished in Trpm8–/– mice.Showed no change falling latencies in mice in the rotarod test.Reduced Capsaicin-induced nocifensive behavior.
体外研究：
Acoltremon (10 μM) shows TRPM8 agonism in tests on heterologously expressed TRP ion channels.Acoltremon (1 or 10 μM; 0-250 s) shows highly potent and specific TRPM8 channel agonist in DRG neurons.
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