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编 号：F426074
分子式：C10H7Cl2N3O
分子量：256.09
分子式：C10H7Cl2N3O
分子量：256.09
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CAS No: 68475-42-3
产品详情
生物活性：
Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36?nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action.
体内研究：
Anagrelide (5 mg/kg/bid；持续 10 天) 抑制或减少 GIST2B、GIST9、GIST882 模型中的肿瘤生长。Animal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model
Dosage:5 mg/kg
Administration:Twice daily; for 10 days
Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
体外研究：
Anagrelide 有效抑制骨髓巨核细胞的发育 (IC50=26?nM)。Anagrelide(0.05、0.3、1 μM；12 天) 仅抑制巨核细胞生长，不抑制非巨核细胞生长。Anagrelide (0.1-10000 nM) 在 GIST882 细胞系中诱导细胞毒性作用。
Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36?nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action.
体内研究：
Anagrelide (5 mg/kg/bid；持续 10 天) 抑制或减少 GIST2B、GIST9、GIST882 模型中的肿瘤生长。Animal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model
Dosage:5 mg/kg
Administration:Twice daily; for 10 days
Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
体外研究：
Anagrelide 有效抑制骨髓巨核细胞的发育 (IC50=26?nM)。Anagrelide(0.05、0.3、1 μM；12 天) 仅抑制巨核细胞生长，不抑制非巨核细胞生长。Anagrelide (0.1-10000 nM) 在 GIST882 细胞系中诱导细胞毒性作用。
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