产品
编 号：F425934
分子式：C31H34O4
分子量：470.6
分子式：C31H34O4
分子量：470.6
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 684238-37-7
产品详情
生物活性：
BMS-986187 is an δ-opioid receptor-selective positive allosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB?of 6.02 (～1?μM). BMS-986187 has no observable PAM activity at the?μ-receptor (EC50=3 μM).
体外研究：
BMS-986187?(1 nM-100 uM) produces little or no activity in agonist mode, but in PAM mode (in the presence of an EC20?of leu-enkephalin (in CHO-OPRD1 cells) or endomorphin 1 (in CHO-OPRM1 cells)) produces a response with an EC50?of 48 nM in CHO-OPRD1 cells and 2?μM in CHO-OPRM1 cells.
BMS-986187 is an δ-opioid receptor-selective positive allosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB?of 6.02 (～1?μM). BMS-986187 has no observable PAM activity at the?μ-receptor (EC50=3 μM).
体外研究：
BMS-986187?(1 nM-100 uM) produces little or no activity in agonist mode, but in PAM mode (in the presence of an EC20?of leu-enkephalin (in CHO-OPRD1 cells) or endomorphin 1 (in CHO-OPRM1 cells)) produces a response with an EC50?of 48 nM in CHO-OPRD1 cells and 2?μM in CHO-OPRM1 cells.
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