产品
编 号:F425754
分子式:C11H9FN2O3
分子量:236.2
产品类型
结构图
CAS No: 68367-52-2
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产品详情
生物活性:
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
体内研究:
Sorbinil (10 mg/kg;腹腔注射;单剂量) 可减轻 LPS 诱导的小鼠眼葡萄膜炎。
体外研究:
Sorbinil (10 μM;24 h) 可抑制醛糖还原酶,并减弱 Raw264.7 小鼠巨噬细胞中 LPS 诱导的氧化应激/ROS 产生。