产品
编 号：F425340
分子式：C22H30N2O
分子量：338.49
分子式：C22H30N2O
分子量：338.49
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CAS No: 68252-19-7
产品详情
生物活性：
Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation.
体内研究：
Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs.Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.).Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.).Animal Model:Conscious, coronary artery ligated dogs
Dosage:Oral administration (p.o.)
Administration:2.5 and 5 mg/kg
Result:Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.
体外研究：
Pirmenol (1 μM) inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells.Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes.Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers.
Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation.
体内研究：
Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs.Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.).Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.).Animal Model:Conscious, coronary artery ligated dogs
Dosage:Oral administration (p.o.)
Administration:2.5 and 5 mg/kg
Result:Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.
体外研究：
Pirmenol (1 μM) inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells.Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes.Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers.
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