产品
编 号:F425125
分子式:C12H12N2O4S2
分子量:312.36
产品类型
结构图
CAS No: 68181-17-9
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产品详情
生物活性:
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
体外研究:
Equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) are activated using SPDP.