产品
编 号:F424938
分子式:C30H46O3
分子量:454.68
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1mg
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5mg
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生物活性:
Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA).

体外研究:
The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL. The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression.
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