产品
编 号：F424885
分子式：C51H82O21
分子量：1031.18
分子式：C51H82O21
分子量：1031.18
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 68124-04-9
产品详情
生物活性：
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
体内研究：
Paris saponin VII (Chonglou Saponin VII) (静脉给药) 显著增强阿霉素对裸鼠 MCF-7/ADR 异种移植模型的抗癌作用。
体外研究：
Paris saponin VII (Chonglou Saponin VII) 以剂量依赖的方式抑制耐阿霉素的人白血病细胞 (K562/ADR) 的生长。Paris saponin VII 通过细胞周期停滞在 G0/G1 期显著抑制细胞增殖。
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
体内研究：
Paris saponin VII (Chonglou Saponin VII) (静脉给药) 显著增强阿霉素对裸鼠 MCF-7/ADR 异种移植模型的抗癌作用。
体外研究：
Paris saponin VII (Chonglou Saponin VII) 以剂量依赖的方式抑制耐阿霉素的人白血病细胞 (K562/ADR) 的生长。Paris saponin VII 通过细胞周期停滞在 G0/G1 期显著抑制细胞增殖。
产品资料
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