产品
编 号：F424309
分子式：C19H36ClNO2
分子量：345.95
分子式：C19H36ClNO2
分子量：345.95
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
500mg
询价
询价
结构图
CAS No: 67-92-5
产品详情
生物活性：
Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.
体内研究：
Dicyclomine hydrochloride (腹膜内注射；8 mg/kg；每天) 会加剧所有测量中的认知障碍。此外，与 Dicyclomine hydrochloride 处理的 NonTg 小鼠相比，Dicyclomine hydrochloride 处理的 3xTg-AD 小鼠的记忆障碍更严重。 Dicyclomine hydrochloride (腹腔注射；2.0、4.0 和 8.0) mg/kg；7 天) 对小鼠配对联想学习 (PAL) 任务的表现产生非常显著的影响。较低剂量的全身处理显示小鼠在空间任务中的行为障碍。Animal Model:C57Bl/6 mice
Dosage:2.0, 4.0, and 8.0 mg/kg
Administration:Intraperitoneal injection; daily; 7 days
Result:Produced impairments due to actions of the agent outside of the hippocampus.
Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.
体内研究：
Dicyclomine hydrochloride (腹膜内注射；8 mg/kg；每天) 会加剧所有测量中的认知障碍。此外，与 Dicyclomine hydrochloride 处理的 NonTg 小鼠相比，Dicyclomine hydrochloride 处理的 3xTg-AD 小鼠的记忆障碍更严重。 Dicyclomine hydrochloride (腹腔注射；2.0、4.0 和 8.0) mg/kg；7 天) 对小鼠配对联想学习 (PAL) 任务的表现产生非常显著的影响。较低剂量的全身处理显示小鼠在空间任务中的行为障碍。Animal Model:C57Bl/6 mice
Dosage:2.0, 4.0, and 8.0 mg/kg
Administration:Intraperitoneal injection; daily; 7 days
Result:Produced impairments due to actions of the agent outside of the hippocampus.
产品资料
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