产品
编 号:F424270
分子式:C19H15N3O
分子量:301.34
产品类型
结构图
CAS No: 67909-49-3
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产品详情
生物活性:
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.
体外研究:
Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expressionand prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression.