产品
编 号：F424014
分子式：C22H23N3O2S
分子量：393.5
分子式：C22H23N3O2S
分子量：393.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 678158-55-9
产品详情
生物活性：
CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.
体内研究：
CLZ-8 (0-400 mg/kg; i.g.; once) shows powerful anti-radiation effects in mice.Animal Model:6-8 week-old male BALB/c mice
Dosage:100, 200 and 400 mg/kg
Administration:Intragastric administration, once, 30 min prior to irradiation
Result:Increased the survival rate of irradiated mice.
体外研究：
CLZ-8 (Compound 8) (0-160 μM, 48 h) significantly inhibits PUMA-dependent apoptosis.CLZ-8 (0-1 μM, 2 h) significantly enhance the irradiated cell viability in a dose-dependent manner, provides significant protection for HUVECs, and inhibits overexpressed PUMA.CLZ-8 (0-1 μM, 24 h) attenuates the radiation-induced apoptosis.CLZ-8 (1 μM, 2 h) protects HUVECs from DNA breaks.
CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.
体内研究：
CLZ-8 (0-400 mg/kg; i.g.; once) shows powerful anti-radiation effects in mice.Animal Model:6-8 week-old male BALB/c mice
Dosage:100, 200 and 400 mg/kg
Administration:Intragastric administration, once, 30 min prior to irradiation
Result:Increased the survival rate of irradiated mice.
体外研究：
CLZ-8 (Compound 8) (0-160 μM, 48 h) significantly inhibits PUMA-dependent apoptosis.CLZ-8 (0-1 μM, 2 h) significantly enhance the irradiated cell viability in a dose-dependent manner, provides significant protection for HUVECs, and inhibits overexpressed PUMA.CLZ-8 (0-1 μM, 24 h) attenuates the radiation-induced apoptosis.CLZ-8 (1 μM, 2 h) protects HUVECs from DNA breaks.
产品资料
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