产品
编 号：F423943
分子式：C19H23N5O4
分子量：385.42
分子式：C19H23N5O4
分子量：385.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 677773-91-0
产品详情
生物活性：
SM-324405 is a TLR7 agonistic antedrug (EC50 = 50 nM), with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively. SM-324405 is used for immunoresearch of allergic diseases. An antedrug is defined as a locally active compound that is designed to be rapidly metabolized to an inactive form upon entry into the circulation and prevents systemic toxicity by losing its agonistic activity in a plasmatic environment.
体内研究：
SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically.SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min.
体外研究：
SM-324405 is a novel candidate for immunotherapy of allergic diseases.
SM-324405 is a TLR7 agonistic antedrug (EC50 = 50 nM), with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively. SM-324405 is used for immunoresearch of allergic diseases. An antedrug is defined as a locally active compound that is designed to be rapidly metabolized to an inactive form upon entry into the circulation and prevents systemic toxicity by losing its agonistic activity in a plasmatic environment.
体内研究：
SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically.SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min.
体外研究：
SM-324405 is a novel candidate for immunotherapy of allergic diseases.
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