产品
编 号：F423445
分子式：C54H66N10O13
分子量：1063.16
分子式：C54H66N10O13
分子量：1063.16
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CAS No: 676367-27-4
产品详情
生物活性：
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism.
体内研究：
Chemerin-9 (149-157) (0.2 mg/kg; i.p.; daily, for 42 days) alleviates glucose intolerance and IR in PDM mice.Chemerin-9 (149-157) (7.7? μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage.Chemerin-9 (149-157) (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment.Animal Model:PDM mice
Dosage:0.2 mg/kg
Administration:Intraperitoneal injection; daily, for 42 days
Result:Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
Animal Model:ApoE-/- mice
Dosage:7.7 μg /kg
Administration:Subcutaneous injection; daily, for 28 days
Result:Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
Animal Model:ApoE-/- mice
Dosage:7.7 μg /kg
Administration:Subcutaneous injection; daily, for 28 days
Result:Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
Animal Model:Male Kunming mice
Dosage:8 μg/kg
Administration:Intracerebroventrical injection; daily; for 14 days
Result:Increased in the levels of pro-in?ammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
体外研究：
Chemerin-9 (149-157) (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production.
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism.
体内研究：
Chemerin-9 (149-157) (0.2 mg/kg; i.p.; daily, for 42 days) alleviates glucose intolerance and IR in PDM mice.Chemerin-9 (149-157) (7.7? μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage.Chemerin-9 (149-157) (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment.Animal Model:PDM mice
Dosage:0.2 mg/kg
Administration:Intraperitoneal injection; daily, for 42 days
Result:Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
Animal Model:ApoE-/- mice
Dosage:7.7 μg /kg
Administration:Subcutaneous injection; daily, for 28 days
Result:Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
Animal Model:ApoE-/- mice
Dosage:7.7 μg /kg
Administration:Subcutaneous injection; daily, for 28 days
Result:Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
Animal Model:Male Kunming mice
Dosage:8 μg/kg
Administration:Intracerebroventrical injection; daily; for 14 days
Result:Increased in the levels of pro-in?ammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
体外研究：
Chemerin-9 (149-157) (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production.
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