产品
编 号：F422928
分子式：C5H14ClNO
分子量：139.62
分子式：C5H14ClNO
分子量：139.62
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
结构图
CAS No: 67-48-1
产品详情
生物活性：
Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders.
体内研究：
Choline chloride (sc，0.2 和 100 mg/kg/h，24 或 48 小时) 可以减少雌性 C57/Bl6 小鼠术后的损伤性反射，有效减少巨噬细胞释放的肿瘤坏死因子 (TNF)。Animal Model:Postoperative pain model of female C57/Bl6 mice
Dosage:0.2 and 100 mg/kg/h
Administration:Subcutaneous injection, 24 or 48 hours
Result:Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.
体外研究：
Choline chloride (0 或 70 μM，4 天) 可有效减轻细胞凋亡并维持细胞活力。
Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders.
体内研究：
Choline chloride (sc，0.2 和 100 mg/kg/h，24 或 48 小时) 可以减少雌性 C57/Bl6 小鼠术后的损伤性反射，有效减少巨噬细胞释放的肿瘤坏死因子 (TNF)。Animal Model:Postoperative pain model of female C57/Bl6 mice
Dosage:0.2 and 100 mg/kg/h
Administration:Subcutaneous injection, 24 or 48 hours
Result:Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.
体外研究：
Choline chloride (0 或 70 μM，4 天) 可有效减轻细胞凋亡并维持细胞活力。
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