产品
编 号：F422866
分子式：C28H34Cl2N2O
分子量：485.49
分子式：C28H34Cl2N2O
分子量：485.49
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 67469-75-4
产品详情
生物活性：
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
体内研究：
GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.Animal Model:Male Sprague-Dawley rats (180-200 g)
Dosage:10 mg/kg
Administration:Intraperitoneal injection; for 100 minutes
Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
体内研究：
GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.Animal Model:Male Sprague-Dawley rats (180-200 g)
Dosage:10 mg/kg
Administration:Intraperitoneal injection; for 100 minutes
Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
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