产品
编 号：F422755
分子式：C6H10O3
分子量：130.14
分子式：C6H10O3
分子量：130.14
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
280
In-stock
250mg
560
In-stock
500mg
840
In-stock
结构图
CAS No: 674-26-0
产品详情
生物活性：
DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling.
体内研究：
DL-Mevalonolactone 能够改善 C57BL/6 小鼠体内由 statin 引起的肌病 (200 mg/kg，口服，14 天)，没有显示毒性 (2 g/kg，口服，7 天)。Animal Model:C57BL/6 mice with cerivastatin/simvastatin induced myopathy
Dosage:200 mg/kg
Administration:oral gavage
Result:Increased muschle strength and endurance in hanging wire and grip tests.
体外研究：
DL-Mevalonolactone (0.1-1 mM，0-72 h) 诱导炎症反应，IL1B 表达水平升高，诱导氧化应激反应，导致 SOD2，HemeOX 和 ROS 的表达水平提高，线粒体膜去极化。DL-Mevalonolactone (1-2 mM) 可以促进脑中的过氧化作用，抑制 aconitase 的活性。
DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling.
体内研究：
DL-Mevalonolactone 能够改善 C57BL/6 小鼠体内由 statin 引起的肌病 (200 mg/kg，口服，14 天)，没有显示毒性 (2 g/kg，口服，7 天)。Animal Model:C57BL/6 mice with cerivastatin/simvastatin induced myopathy
Dosage:200 mg/kg
Administration:oral gavage
Result:Increased muschle strength and endurance in hanging wire and grip tests.
体外研究：
DL-Mevalonolactone (0.1-1 mM，0-72 h) 诱导炎症反应，IL1B 表达水平升高，诱导氧化应激反应，导致 SOD2，HemeOX 和 ROS 的表达水平提高，线粒体膜去极化。DL-Mevalonolactone (1-2 mM) 可以促进脑中的过氧化作用，抑制 aconitase 的活性。
产品资料
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