产品
编 号：F422701
分子式：C24H30O3
分子量：366.49
分子式：C24H30O3
分子量：366.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
300
In-stock
10mg
480
In-stock
50mg
1440
In-stock
100mg
1920
In-stock
结构图
CAS No: 67392-87-4
产品详情
生物活性：
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .
体内研究：
Drospirenone (10-100 mg/kg, oral gavage for five days) 导致成年雌性小鼠骨髓细胞 DNA 损伤。Animal Model:Adult female mice
Dosage:10 mg/kg, 100mg/kg
Administration:Oral gavage (p.o.)
Result:Caused DNA damage at dose rates of 10 and 100 mg/kg.Enhanced the genotoxicity combinated with ethinylestradiol.
体外研究：
Drospirenone (10-150 μM, 24-48 h) 对 PLHC-1 细胞的毒性作用的 EC50 值为 (105-119 μM，24 小时) 和 (51-58 μM，48 小时)。Drospirenone (10-200 μM, 15-120 min) 增加 PLHC-1 细胞内 ROS 的产生。Drospirenone (0.01-10 μM, 24 h) 抑制 HEEC 中 PAI-1 和 tPA 的分泌。Drospirenone (1-100 μM, 72 h) 在添加小鼠肝脏 S9 成分时，会导致 MCF-7 细胞的 DNA 损伤。
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .
体内研究：
Drospirenone (10-100 mg/kg, oral gavage for five days) 导致成年雌性小鼠骨髓细胞 DNA 损伤。Animal Model:Adult female mice
Dosage:10 mg/kg, 100mg/kg
Administration:Oral gavage (p.o.)
Result:Caused DNA damage at dose rates of 10 and 100 mg/kg.Enhanced the genotoxicity combinated with ethinylestradiol.
体外研究：
Drospirenone (10-150 μM, 24-48 h) 对 PLHC-1 细胞的毒性作用的 EC50 值为 (105-119 μM，24 小时) 和 (51-58 μM，48 小时)。Drospirenone (10-200 μM, 15-120 min) 增加 PLHC-1 细胞内 ROS 的产生。Drospirenone (0.01-10 μM, 24 h) 抑制 HEEC 中 PAI-1 和 tPA 的分泌。Drospirenone (1-100 μM, 72 h) 在添加小鼠肝脏 S9 成分时，会导致 MCF-7 细胞的 DNA 损伤。
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