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编 号：F422618
分子式：C7H9N2O+
分子量：137.16
分子式：C7H9N2O+
分子量：137.16
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CAS No: 6735-59-7
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生物活性：
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.
体内研究：
Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice.Animal Model:F1B6D2 mice (male, administered subcutaneously diethylparaoxon)
Dosage:10, 50, 100, and 150 mg/kg
Administration:Intramuscular administration, once
Result:Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.
体内研究：
Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice.Animal Model:F1B6D2 mice (male, administered subcutaneously diethylparaoxon)
Dosage:10, 50, 100, and 150 mg/kg
Administration:Intramuscular administration, once
Result:Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
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