产品
编 号：F422167
分子式：C17H20ClNO6S
分子量：401.86
分子式：C17H20ClNO6S
分子量：401.86
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 67227-57-0
产品详情
生物活性：
Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis.
体内研究：
Fenoldopam mesylate (subcutaneous injection; 100 mg/kg; once daily; 2 d) can induce arteritis in rats detected by magnetic resonance imaging (MRI).Animal Model:Female Sprague-Dawley rats
Dosage:100 mg/kg
Administration:Subcutaneous injection; 100 mg/kg; once daily; 2 days
Result:Showed low-intensity areas and a high signal intensity region around the artery, and these findings were considered to be erythrocytes infiltrating the arterial wall and perivascular edema, respectively.Observed perivascular edema histopathologically.
体外研究：
Fenoldopam is a partial agonist with low efficacy at DA1 receptors linked to cAMP generation in the LLC-PK1 cells.Fenoldopam (0-300 μM; 48 or 72 h) displays significant antiproliferative activity against RCC cell lines.Fenoldopam (5 μM and 10 μM; 72 h) induces cell apoptosis in a dose-dependent manner.
Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis.
体内研究：
Fenoldopam mesylate (subcutaneous injection; 100 mg/kg; once daily; 2 d) can induce arteritis in rats detected by magnetic resonance imaging (MRI).Animal Model:Female Sprague-Dawley rats
Dosage:100 mg/kg
Administration:Subcutaneous injection; 100 mg/kg; once daily; 2 days
Result:Showed low-intensity areas and a high signal intensity region around the artery, and these findings were considered to be erythrocytes infiltrating the arterial wall and perivascular edema, respectively.Observed perivascular edema histopathologically.
体外研究：
Fenoldopam is a partial agonist with low efficacy at DA1 receptors linked to cAMP generation in the LLC-PK1 cells.Fenoldopam (0-300 μM; 48 or 72 h) displays significant antiproliferative activity against RCC cell lines.Fenoldopam (5 μM and 10 μM; 72 h) induces cell apoptosis in a dose-dependent manner.
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