产品
编 号：F421622
分子式：C19H22N2O
分子量：294.39
分子式：C19H22N2O
分子量：294.39
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 669770-29-0
产品详情
生物活性：
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety.
体内研究：
VQW-765 (0.03 和 0.3 mg/kg；口服，一次) 增加小鼠的认知和学习、记忆表现。VQW-765 (1 mg/kg；口服，一次) 显示出抗焦虑作用，增加大鼠的社会探索时间，持续时间至少6小时。Animal Model:OF1/IC strain adult mice
Dosage:0.03 and 0.3 mg/kg
Administration:Oral administration; 0.03 and 0.3 mg/kg once
Result:Increased the learning/memory performance with more time to scrutinize the novel partner than the familiar partner during the re-test trial at 24 h. Showed cognitive-enhancing effects in mice by the object recognition test (ORT).
体外研究：
VQW-765 对重组表达的人 α7-nACh 受体的 pKD 值为 7.56。VQW-765 在 GH3-ha7-22 细胞中重组表达的人 α7-nACh 受体刺激后，显示出对钙瞬态的强大激动活性，pEC50 值为 7.41。
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety.
体内研究：
VQW-765 (0.03 和 0.3 mg/kg；口服，一次) 增加小鼠的认知和学习、记忆表现。VQW-765 (1 mg/kg；口服，一次) 显示出抗焦虑作用，增加大鼠的社会探索时间，持续时间至少6小时。Animal Model:OF1/IC strain adult mice
Dosage:0.03 and 0.3 mg/kg
Administration:Oral administration; 0.03 and 0.3 mg/kg once
Result:Increased the learning/memory performance with more time to scrutinize the novel partner than the familiar partner during the re-test trial at 24 h. Showed cognitive-enhancing effects in mice by the object recognition test (ORT).
体外研究：
VQW-765 对重组表达的人 α7-nACh 受体的 pKD 值为 7.56。VQW-765 在 GH3-ha7-22 细胞中重组表达的人 α7-nACh 受体刺激后，显示出对钙瞬态的强大激动活性，pEC50 值为 7.41。
产品资料
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