产品
编 号：F421078
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 667901-13-5
产品详情
生物活性：
Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer.
体内研究：
Zalutumumab (5 mg/kg; i.p. 2 h after tumor induction) affects tumor growth in A431 xenograft models.Zalutumumab (0.5 and 5 mg/kg; i.p. once ) delays tumor growth when mice with tumor volumes of 80-100 mm3.Animal Model:SCID mice with A431 cells injection
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg 2 hours after tumor induction
Result:Effectively inhibited tumor growth in A431 xenograft models with an early treatment.
体外研究：
Zalutumumab (0-1 μM; 60 min) effectively blocks EGF-induced EGFR activation with an IC50 value of 1.3 nM.Zalutumumab (0-1 μM; 96 h) affects proliferation of A431 cells.Zalutumumab (10 μg/mL; 24 h) induces a comparable percentage of specificlysis of A431 cells with mouse macrophages.
Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer.
体内研究：
Zalutumumab (5 mg/kg; i.p. 2 h after tumor induction) affects tumor growth in A431 xenograft models.Zalutumumab (0.5 and 5 mg/kg; i.p. once ) delays tumor growth when mice with tumor volumes of 80-100 mm3.Animal Model:SCID mice with A431 cells injection
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg 2 hours after tumor induction
Result:Effectively inhibited tumor growth in A431 xenograft models with an early treatment.
体外研究：
Zalutumumab (0-1 μM; 60 min) effectively blocks EGF-induced EGFR activation with an IC50 value of 1.3 nM.Zalutumumab (0-1 μM; 96 h) affects proliferation of A431 cells.Zalutumumab (10 μg/mL; 24 h) induces a comparable percentage of specificlysis of A431 cells with mouse macrophages.
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