产品
编 号：F048876
分子式：C21H19ClN2O2
分子量：366.84
分子式：C21H19ClN2O2
分子量：366.84
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1155877-97-6
产品详情
生物活性：
D159687 is a selective PDE4D inhibitor.
体内研究：
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.Animal Model:Female Cynomolgus macaques (4–6 year old)
Dosage:0.05, 0.5, 5 mg/kg
Administration:Oral daily for a week
Result:A potential recruitment or enhancement of synaptic function with increased task difficulty.
体外研究：
D159687 (1 μM, 0-24?hours) induces a transient increase in CREB phosphorylation which peaked at 6?hours after treatment.D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1?μM.
D159687 is a selective PDE4D inhibitor.
体内研究：
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.Animal Model:Female Cynomolgus macaques (4–6 year old)
Dosage:0.05, 0.5, 5 mg/kg
Administration:Oral daily for a week
Result:A potential recruitment or enhancement of synaptic function with increased task difficulty.
体外研究：
D159687 (1 μM, 0-24?hours) induces a transient increase in CREB phosphorylation which peaked at 6?hours after treatment.D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1?μM.
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