产品
编 号：F420594
分子式：C14H16N2O.1/2C4H6O4
分子量：287.34
分子式：C14H16N2O.1/2C4H6O4
分子量：287.34
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CAS No: 66611-27-6
产品详情
生物活性：
RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion.
体内研究：
RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats.RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion.Animal Model:Male Sprague-Dawley rats
Dosage:0.03, 0.3, 1.0, 3.0 mg/kg
Administration:A single s.c.
Result:Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
体外研究：
RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro.
RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion.
体内研究：
RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats.RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion.Animal Model:Male Sprague-Dawley rats
Dosage:0.03, 0.3, 1.0, 3.0 mg/kg
Administration:A single s.c.
Result:Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
体外研究：
RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro.
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