产品
编 号：F420527
分子式：C10H18ClN
分子量：187.71
分子式：C10H18ClN
分子量：187.71
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
240
In-stock
5g
480
In-stock
10g
640
In-stock
50g
1040
In-stock
结构图
CAS No: 665-66-7
产品详情
生物活性：
Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.
体内研究：
Amantadine hydrochloride (25 mg/kg，IP，每天一次，持续 3 天) 抑制手术引起的神经炎症和学习记忆障碍。Animal Model:Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)
Dosage:25 mg/kg
Administration:IP, once daily for 3 days (the first dose at 15 min before surgery)
Result:Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
体外研究：
Amantadine hydrochloride (0-500 μM，26 小时) 抑制 SARS-CoV-2 复制，IC50 浓度在 83 和 119 μM 之间。 Amantadine hydrochloride (0-100 μg/mL，24-72 h) 显著抑制 HepG2 和 SMMC-7721 细胞的增殖。 Amantadine hydrochloride (0-75 μg/mL，48 h) 将细胞周期阻滞在 G0/G1 期并诱导细胞凋亡。 Amantadine hydrochloride (0-75 μg/mL，48 h) 可降低细胞周期相关基因和蛋白 (cyclin D1、cyclin E 和 CDK2)，减少 Bcl-2 并增加 Bax 蛋白和 mRNA 水平。
Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.
体内研究：
Amantadine hydrochloride (25 mg/kg，IP，每天一次，持续 3 天) 抑制手术引起的神经炎症和学习记忆障碍。Animal Model:Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)
Dosage:25 mg/kg
Administration:IP, once daily for 3 days (the first dose at 15 min before surgery)
Result:Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
体外研究：
Amantadine hydrochloride (0-500 μM，26 小时) 抑制 SARS-CoV-2 复制，IC50 浓度在 83 和 119 μM 之间。 Amantadine hydrochloride (0-100 μg/mL，24-72 h) 显著抑制 HepG2 和 SMMC-7721 细胞的增殖。 Amantadine hydrochloride (0-75 μg/mL，48 h) 将细胞周期阻滞在 G0/G1 期并诱导细胞凋亡。 Amantadine hydrochloride (0-75 μg/mL，48 h) 可降低细胞周期相关基因和蛋白 (cyclin D1、cyclin E 和 CDK2)，减少 Bcl-2 并增加 Bax 蛋白和 mRNA 水平。
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