产品
编 号：F420462
分子式：C16H22N6O4S
分子量：394.45
分子式：C16H22N6O4S
分子量：394.45
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CAS No: 66537-55-1
产品详情
生物活性：
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome.
体内研究：
MK771 (5 mg/kg；腹腔注射) 诱导小鼠眨眼和前爪舔。MK771 (10 ng-10 μg/小鼠；i.c.v.) 在小鼠体内产生高热反应。Animal Model:20-30 g, male MF1 mice
Dosage:5 mg/kg
Administration:I.p.
Result:Induced blinking and forepaw licking in both acutely isolated and paired mice.
Animal Model:20-30 g, male MF1 mice
Dosage:0.25-60 mg/kg
Administration:I.p.
Result:Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg.
Animal Model:25-30 g, Male Swiss-Webster mice
Dosage:10 ng-10 μg/mouse
Administration:I.c.v.
Result:Produced a hyperthermic response for 4 h followed by a return to normal temperature.
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome.
体内研究：
MK771 (5 mg/kg；腹腔注射) 诱导小鼠眨眼和前爪舔。MK771 (10 ng-10 μg/小鼠；i.c.v.) 在小鼠体内产生高热反应。Animal Model:20-30 g, male MF1 mice
Dosage:5 mg/kg
Administration:I.p.
Result:Induced blinking and forepaw licking in both acutely isolated and paired mice.
Animal Model:20-30 g, male MF1 mice
Dosage:0.25-60 mg/kg
Administration:I.p.
Result:Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg.
Animal Model:25-30 g, Male Swiss-Webster mice
Dosage:10 ng-10 μg/mouse
Administration:I.c.v.
Result:Produced a hyperthermic response for 4 h followed by a return to normal temperature.
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