产品
编 号：F420381
分子式：C11H11Cl2N
分子量：228.12
分子式：C11H11Cl2N
分子量：228.12
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 66504-40-3
产品详情
生物活性：
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats.
体内研究：
Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals.Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations.Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.
Dosage:20 mg/kg.
Administration:I.P. daily for 17days.
Result:Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.
Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.
Dosage:20 mg/kg.
Administration:I.P. once.
Result:Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats.
体内研究：
Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals.Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations.Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.
Dosage:20 mg/kg.
Administration:I.P. daily for 17days.
Result:Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.
Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.
Dosage:20 mg/kg.
Administration:I.P. once.
Result:Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.
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