产品
编 号：F419325
分子式：C30H50O2
分子量：442.72
分子式：C30H50O2
分子量：442.72
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CAS No: 6610-56-6
产品详情
生物活性：
Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity.
体内研究：
Glochidiol (60 mg/kg/day; i.g.; 21 days) 在裸鼠中有效抑制肺癌 HCC-44 异种移植瘤生长。Animal Model:BALB/c nude mice bearing HCC-44 xenografts
Dosage:60 mg/kg/day
Administration:Intragastric administration for a period of 21 days
Result:Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney.
体外研究：
Glochidiol (1-8 μM; 48 h) 对肺癌细胞系显示出强效的抗增殖活性，且呈浓度依赖性。Glochidiol 通过靶向秋水仙碱结合位点与微管蛋白相互作用。
Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity.
体内研究：
Glochidiol (60 mg/kg/day; i.g.; 21 days) 在裸鼠中有效抑制肺癌 HCC-44 异种移植瘤生长。Animal Model:BALB/c nude mice bearing HCC-44 xenografts
Dosage:60 mg/kg/day
Administration:Intragastric administration for a period of 21 days
Result:Decreased average tumor weight and relative tumor volume with no obvious cytotoxic effect on the major organs, including heart, liver, and kidney.
体外研究：
Glochidiol (1-8 μM; 48 h) 对肺癌细胞系显示出强效的抗增殖活性，且呈浓度依赖性。Glochidiol 通过靶向秋水仙碱结合位点与微管蛋白相互作用。
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