产品
编 号：F419321
分子式：C20H30N2O3S2
分子量：410.59
分子式：C20H30N2O3S2
分子量：410.59
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
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25mg
询价
询价
50mg
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询价
结构图
CAS No: 66104-23-2
产品详情
生物活性：
Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research.
体内研究：
Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .Animal Model:Wistar rats (200-250 g) induced with 6-hydroxydopamine (6-OHDA)
Dosage:0.3 mg/kg
Administration:Intraperitoneal injection; daily; 11 days
Result:A reduced number of working/reference memory errors was observed. And significant decreased of MDA level.
体外研究：
Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.
Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research.
体内研究：
Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .Animal Model:Wistar rats (200-250 g) induced with 6-hydroxydopamine (6-OHDA)
Dosage:0.3 mg/kg
Administration:Intraperitoneal injection; daily; 11 days
Result:A reduced number of working/reference memory errors was observed. And significant decreased of MDA level.
体外研究：
Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.
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