产品
编 号:F419037
分子式:C10H10F3N3
分子量:229.2
产品类型
结构图
CAS No: 66000-40-6
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产品详情
生物活性:
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively.
体内研究:
BW 755C (0.03-10 mg/rat; s.c.; once) 抑制大鼠排卵率及卵巢 5-HETE 和 12-HETE 水平。Animal Model:Immature Wistar rats ~22 days of age
Dosage:0.03, 0.1, 0.3, 1.0, 3.1 and 10 mg/rat
Administration:Subcutaneous injection, once
Result:Reduced 5-HETE (moderately) and 12-HETE (strongly).