产品
编 号：F418999
分子式：C34H22O22
分子量：782.53
分子式：C34H22O22
分子量：782.53
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 65995-64-4
产品详情
生物活性：
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity.
体内研究：
Punicalin (5 mg/kg, 皮下注射) 对 Carrageenan (HY-125474) 诱导的大鼠足跖水肿有明显的抗炎作用。Punicalin (10 mg/kg, 腹腔注射) 通过抑制炎性细胞因子的产生和 MAPK/ NF-κB 信号传导来减轻 Lipopolysaccharide (HY-D1056) 诱导的小鼠急性肺损伤。Animal Model:Carrageenan (HY-125474)-induced Edema in rats
Dosage:5 mg/kg
Administration:s.c.
Result:Showed significant anti-inflammatory effect against carrageenan induced paw edema at all time intervals, but decreased the effects.with larger dose.
Animal Model:LPS (HY-D1056)-induced acute lung injury mice
Dosage:10 mg/kg
Administration:i.p.
Result:Reduced the mortality and attenuated the severity of lung pathological injury.Ameliorated LPS (HY-D1056)-induced lung edema and vascular leakage.
体外研究：
Punicalin (0-100 μM, 24 h) 在小鼠单核巨噬细胞 J774A 中通过抑制 ROS/NLRP3 通路改善 LPS/ATP 诱导的细胞焦亡。Punicalin (10, 20 μM, 24 h) 通过 TGF-β 介导的神经母细胞瘤 SH-SY5Y 氧化应激和细胞周期减轻 OGD/R 引发的细胞损伤。
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity.
体内研究：
Punicalin (5 mg/kg, 皮下注射) 对 Carrageenan (HY-125474) 诱导的大鼠足跖水肿有明显的抗炎作用。Punicalin (10 mg/kg, 腹腔注射) 通过抑制炎性细胞因子的产生和 MAPK/ NF-κB 信号传导来减轻 Lipopolysaccharide (HY-D1056) 诱导的小鼠急性肺损伤。Animal Model:Carrageenan (HY-125474)-induced Edema in rats
Dosage:5 mg/kg
Administration:s.c.
Result:Showed significant anti-inflammatory effect against carrageenan induced paw edema at all time intervals, but decreased the effects.with larger dose.
Animal Model:LPS (HY-D1056)-induced acute lung injury mice
Dosage:10 mg/kg
Administration:i.p.
Result:Reduced the mortality and attenuated the severity of lung pathological injury.Ameliorated LPS (HY-D1056)-induced lung edema and vascular leakage.
体外研究：
Punicalin (0-100 μM, 24 h) 在小鼠单核巨噬细胞 J774A 中通过抑制 ROS/NLRP3 通路改善 LPS/ATP 诱导的细胞焦亡。Punicalin (10, 20 μM, 24 h) 通过 TGF-β 介导的神经母细胞瘤 SH-SY5Y 氧化应激和细胞周期减轻 OGD/R 引发的细胞损伤。
产品资料
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