产品
编 号：F418851
分子式：C20H25NO2
分子量：311.42
分子式：C20H25NO2
分子量：311.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
250
In-stock
10mg
400
In-stock
50mg
720
In-stock
100mg
1200
In-stock
结构图
CAS No: 65928-58-7
产品详情
生物活性：
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.
体内研究：
Dienogest (1 mg/kg；口服每天一次，持续 14 天) 在大鼠子宫内膜自体移植模型中调节异位子宫内膜病变的血管生成。Animal Model:Female Wistar rats (8 to 10-week-old; 180-220 g; rat endometrial autograft model).
Dosage:1 mg/kg
Administration:Oral administration; once daily for 14 days.
Result:Showed significant suppression of angiogenesis of endometrial autografts, as indicated by the reduced size of the microvascular network and decreased microvessel density.Significantly reduced the level of perivascular α-smooth muscle actin within endometrial grafts.
体外研究：
Dienogest (0.01-1 μM；24 h) 通过抑制 PGE2 合酶基因表达抑制 PGE2 的产生，同时抑制球体培养物中的 NF-κB 活性。 Dienogest (0.1 μM；24 h) 以不依赖于 PGE2 的方式抑制芳香酶表达基因以及 COUP-TFII mRNA 的表达。
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.
体内研究：
Dienogest (1 mg/kg；口服每天一次，持续 14 天) 在大鼠子宫内膜自体移植模型中调节异位子宫内膜病变的血管生成。Animal Model:Female Wistar rats (8 to 10-week-old; 180-220 g; rat endometrial autograft model).
Dosage:1 mg/kg
Administration:Oral administration; once daily for 14 days.
Result:Showed significant suppression of angiogenesis of endometrial autografts, as indicated by the reduced size of the microvascular network and decreased microvessel density.Significantly reduced the level of perivascular α-smooth muscle actin within endometrial grafts.
体外研究：
Dienogest (0.01-1 μM；24 h) 通过抑制 PGE2 合酶基因表达抑制 PGE2 的产生，同时抑制球体培养物中的 NF-κB 活性。 Dienogest (0.1 μM；24 h) 以不依赖于 PGE2 的方式抑制芳香酶表达基因以及 COUP-TFII mRNA 的表达。
产品资料
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