产品
编 号：F418828
分子式：C21H30N2O7S
分子量：405.5
分子式：C21H30N2O7S
分子量：405.5
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CAS No: 6591-63-5
产品详情
生物活性：
Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research.
体内研究：
Quinidine sulfate dihydrate shows effects on the PTZ-induced seizure threshold.Animal Model:Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)
Dosage:10, 20, and 30 mg/kg
Administration:Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result:Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
体外研究：
Quinidine sulfate dihydrate shows cytotoxicity against MES-SA cells, and induces apoptosis.
Quinidine sulfate dihydrate is an antiarrhythmic agent. Quinidine sulfate dihydrate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate dihydrate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine sulfate dihydrate can be used for malaria research.
体内研究：
Quinidine sulfate dihydrate shows effects on the PTZ-induced seizure threshold.Animal Model:Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)
Dosage:10, 20, and 30 mg/kg
Administration:Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result:Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
体外研究：
Quinidine sulfate dihydrate shows cytotoxicity against MES-SA cells, and induces apoptosis.
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