产品
编 号：F418644
分子式：C11H14ClNO3
分子量：243.69
分子式：C11H14ClNO3
分子量：243.69
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
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100mg
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200mg
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500mg
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结构图
CAS No: 65836-72-8
产品详情
生物活性：
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.
体内研究：
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
体外研究：
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively.
DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.
体内研究：
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
体外研究：
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively.
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