产品
编 号：F418584
分子式：C59H84N18O14
分子量：1269.41
分子式：C59H84N18O14
分子量：1269.41
产品类型
规格
价格
是否有货
结构图
CAS No: 65807-02-5
产品详情
生物活性：
Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.
体内研究：
Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors.Animal Model:Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g),subcutaneous xenograft tumor model
Dosage:100 μg/mice
Administration:Subcutaneous injection, daily, for 19 days
Result:Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors
体外研究：
Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis.Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genesin SKOV3-ip cells.Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway.
Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.
体内研究：
Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors.Animal Model:Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g),subcutaneous xenograft tumor model
Dosage:100 μg/mice
Administration:Subcutaneous injection, daily, for 19 days
Result:Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors
体外研究：
Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis.Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genesin SKOV3-ip cells.Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备