产品
编 号：F418293
分子式：C14H13BrN2O
分子量：305.17
分子式：C14H13BrN2O
分子量：305.17
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 65678-07-1
产品详情
生物活性：
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity.
体内研究：
AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth. Animal Model:Female nude mice (6-8 weeks old)
Dosage:30 μg
Administration:IP; per day; for 2 weeks
Result:Significantly delayed the tumour growth.
体外研究：
AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation. AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis. AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs.
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity.
体内研究：
AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth. Animal Model:Female nude mice (6-8 weeks old)
Dosage:30 μg
Administration:IP; per day; for 2 weeks
Result:Significantly delayed the tumour growth.
体外研究：
AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation. AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis. AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs.
产品资料
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