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编 号:F418080
分子式:C17H16ClNO
分子量:285.77
产品类型
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CAS No: 65576-45-6
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生物活性:
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.
体内研究:
Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy.Animal Model:Adult male Wistar rats (200-250 g)
Dosage:0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg
Administration:Subcutaneous injection
Result:Produced suppression of CAR in a dose-dependent manner.