产品
编 号：F417632
分子式：C22H18O12
分子量：474.37
分子式：C22H18O12
分子量：474.37
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 6537-80-0
产品详情
生物活性：
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects.
体内研究：
Chicoric acid（Chicoric acid；60 mg/kg/天；饮水 4 周）可抑制糖尿病小鼠的胰腺细胞凋亡并调整胰岛功能，导致使用链脲佐菌素（STZ；5 0 mg/kg；腹膜内；连续 5 天）的 C57BL/6J 小鼠胰岛素生成和分泌增加。 Animal Model:C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)
Dosage:60 mg/kg
Administration:Drinking water; daily; for 4 weeks
Result:Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses. Showed a remarkable increase in body weight starting at week 7.
体外研究：
Chicoric acid (Cichoric acid；10 -200 μM；持续 24、48 和 72 小时) 导致细胞活力呈剂量和时间依赖性降低。 Chicoric acid (100 μM；48 h) 通过 caspase-3 依赖性途径诱导细胞凋亡。 Chicoric acid (100 μM；48 h) 降低 p-Akt 的蛋白质水平。 Chicoric acid (25、50、100 μM；持续 24 小时) 以剂量依赖性方式显著改善葡萄糖摄取，并且 Chicoric acid 进一步增强胰岛素诱导的 (100 nM；30 分钟) 葡萄糖摄取达 57.7% HepG2细胞。 Chicoric acid (100 μM；24 小时) 通过激活 HepG2 细胞中的 PI3K/Akt 通路恢复葡萄糖胺诱导的 GLUT2 易位损伤。 Chicoric acid (100 μM) 对 HepG2 细胞活力没有影响。
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects.
体内研究：
Chicoric acid（Chicoric acid；60 mg/kg/天；饮水 4 周）可抑制糖尿病小鼠的胰腺细胞凋亡并调整胰岛功能，导致使用链脲佐菌素（STZ；5 0 mg/kg；腹膜内；连续 5 天）的 C57BL/6J 小鼠胰岛素生成和分泌增加。 Animal Model:C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)
Dosage:60 mg/kg
Administration:Drinking water; daily; for 4 weeks
Result:Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses. Showed a remarkable increase in body weight starting at week 7.
体外研究：
Chicoric acid (Cichoric acid；10 -200 μM；持续 24、48 和 72 小时) 导致细胞活力呈剂量和时间依赖性降低。 Chicoric acid (100 μM；48 h) 通过 caspase-3 依赖性途径诱导细胞凋亡。 Chicoric acid (100 μM；48 h) 降低 p-Akt 的蛋白质水平。 Chicoric acid (25、50、100 μM；持续 24 小时) 以剂量依赖性方式显著改善葡萄糖摄取，并且 Chicoric acid 进一步增强胰岛素诱导的 (100 nM；30 分钟) 葡萄糖摄取达 57.7% HepG2细胞。 Chicoric acid (100 μM；24 小时) 通过激活 HepG2 细胞中的 PI3K/Akt 通路恢复葡萄糖胺诱导的 GLUT2 易位损伤。 Chicoric acid (100 μM) 对 HepG2 细胞活力没有影响。
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