产品
编 号:F417404
分子式:C18H23N3O4S
分子量:377.46
产品类型
规格
价格
是否有货
100mg
344
In-stock
500mg
询价
询价
结构图
联系客服
产品详情
生物活性:
Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction.

体内研究:
Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.

体外研究:
Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively.?Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively.?Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) signi?cantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.?Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.
产品资料