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编 号:F047777
分子式:C24H19NO5
分子量:401.41
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10mM*1mL in DMSO
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5mg
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10mg
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50mg
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100mg
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生物活性:
Oxyphenisatin acetate, the pro-agent of oxyphenisatin, is used to be a laxative.

体内研究:
Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model.

体外研究:
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction.
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