产品
编 号:F047777
分子式:C24H19NO5
分子量:401.41
产品类型
结构图
CAS No: 115-33-3
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产品详情
生物活性:
Oxyphenisatin acetate, the pro-agent of oxyphenisatin, is used to be a laxative.
体内研究:
Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model.
体外研究:
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction.