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编 号：F047597
分子式：C32H38Cl2N10O4
分子量：697.61
分子式：C32H38Cl2N10O4
分子量：697.61
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CAS No: 115308-98-0
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生物活性：
Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent.
体内研究：
Tallimustine (3 mg/kg, i.p.) shows antileukaemic activity in L1210 tumor bearing mice.Animal Model:L1210 tumor bearing mice.
Dosage:3 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Prolonged the survival of mice.
体外研究：
Tallimustine (0.1-10 μM, 4 h) induces damage to purified SV40 DNA.Tallimustine (72 h ) shows cytotoxicity in CEM Cells, with an IC50 of 3.5 nM.Tallimustine (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells.Tallimustine (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells.Tallimustine (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase.
Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent.
体内研究：
Tallimustine (3 mg/kg, i.p.) shows antileukaemic activity in L1210 tumor bearing mice.Animal Model:L1210 tumor bearing mice.
Dosage:3 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Prolonged the survival of mice.
体外研究：
Tallimustine (0.1-10 μM, 4 h) induces damage to purified SV40 DNA.Tallimustine (72 h ) shows cytotoxicity in CEM Cells, with an IC50 of 3.5 nM.Tallimustine (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells.Tallimustine (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells.Tallimustine (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase.
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