产品
编 号：F416427
分子式：C8H20N2O6S4
分子量：368.51
分子式：C8H20N2O6S4
分子量：368.51
产品类型
规格
价格
是否有货
1mg
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 648927-86-0
产品详情
生物活性：
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (Ki=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.
体内研究：
Firibastat (0.1-30 mg/kg；po) 穿过胃肠道和血脑屏障，进入大脑，产生两种EC33活性分子，抑制大脑APA活性，阻断脑血管紧张素III的形成，使高血压大鼠血压降低数小时。Animal Model:Normotensive and hypertensive DOCA-salt rats
Dosage:0.1-30 mg/kg
Administration:P.o.
Result:Resulting in a dose-dependent decrease in mean arterial blood pressure (MABP).
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (Ki=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.
体内研究：
Firibastat (0.1-30 mg/kg；po) 穿过胃肠道和血脑屏障，进入大脑，产生两种EC33活性分子，抑制大脑APA活性，阻断脑血管紧张素III的形成，使高血压大鼠血压降低数小时。Animal Model:Normotensive and hypertensive DOCA-salt rats
Dosage:0.1-30 mg/kg
Administration:P.o.
Result:Resulting in a dose-dependent decrease in mean arterial blood pressure (MABP).
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